BDBM8914 Methyl 6-pyridin-3-yl-2-naphthoate::Pyridine-substituted naphthalene 16::US9271963, 16::methyl 6-(pyridin-3-yl)naphthalene-2-carboxylate

SMILES COC(=O)c1ccc2cc(ccc2c1)-c1cccnc1

InChI Key InChIKey=KEAMGKNBYBPPQH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 8914   

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

LigandPNGBDBM8914(methyl 6-(pyridin-3-yl)naphthalene-2-carboxylate |...)
Affinity DataIC50: 72nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

LigandPNGBDBM8914(methyl 6-(pyridin-3-yl)naphthalene-2-carboxylate |...)
Affinity DataIC50: 73nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetAromatase(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8914(methyl 6-(pyridin-3-yl)naphthalene-2-carboxylate |...)
Affinity DataIC50: 1.25E+3nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetAromatase(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8914(methyl 6-(pyridin-3-yl)naphthalene-2-carboxylate |...)
Affinity DataIC50: 1.25E+3nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8914(methyl 6-(pyridin-3-yl)naphthalene-2-carboxylate |...)
Affinity DataIC50: 1.05E+4nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8914(methyl 6-(pyridin-3-yl)naphthalene-2-carboxylate |...)
Affinity DataIC50: 1.05E+4nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed