BDBM102171 US8530648, 85

SMILES Cc1ccc(C)c(CN2C(=O)CCCC22CCN(CC2)c2cnc3ccccc3n2)c1

InChI Key InChIKey=XOEYXHCZYQOOHV-UHFFFAOYSA-N

Data  4 KI  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 102171   

TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM102171(US8530648, 85)
Affinity DataKi:  13nMAssay Description:Antagonist activity at human OX2 receptor expressed in HEK cells assessed as inhibition of orexin A-induced Ca2+ accumulation after 1 hr by Fluo-4-AM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM102171(US8530648, 85)
Affinity DataKi:  16nMpH: 7.4Assay Description:FLIPR assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM102171(US8530648, 85)
Affinity DataKi:  59nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHO cells assessed as inhibition of orexin A-induced Ca2+ accumulation after 1 hr by Fluo-4-AM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM102171(US8530648, 85)
Affinity DataKi:  77nMpH: 7.4Assay Description:FLIPR assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM102171(US8530648, 85)
Affinity DataKd:  100nMpH: 7.5Assay Description:Radioligand binding assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM102171(US8530648, 85)
Affinity DataKd:  36nMpH: 7.5Assay Description:Radioligand binding assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent