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BDBM104227 US8575145, 104

SMILES: CCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1

InChI Key: InChIKey=RYSAKMOLNKFGCG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 104227   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104227
PNG
(US8575145, 104)
Show SMILES CCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C23H24FN5O/c1-2-28-14-11-23(24,12-15-28)16-30-19-7-5-6-17-9-10-18(25-21(17)19)22-27-26-20-8-3-4-13-29(20)22/h3-10,13H,2,11-12,14-16H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 191n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104227
PNG
(US8575145, 104)
Show SMILES CCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Show InChI InChI=1S/C23H24FN5O/c1-2-28-14-11-23(24,12-15-28)16-30-19-7-5-6-17-9-10-18(25-21(17)19)22-27-26-20-8-3-4-13-29(20)22/h3-10,13H,2,11-12,14-16H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.90n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair