BDBM106950 US8592581, 1
SMILES CC[C@H](Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)[C@@H](C)O
InChI Key InChIKey=DLPIYBKBHMZCJI-WBVHZDCISA-N
Data 16 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 106950
Affinity DataIC50: 20nMpH: 7.5 T: 30°CAssay Description:To evaluate the in-vitro kinase potency of the compounds, they were screened against CDK 2 and CDK9. Kinase assays were performed in 96-well plates u...More data for this Ligand-Target Pair
Affinity DataIC50: 193nMAssay Description:Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMpH: 7.5 T: 30°CAssay Description:To evaluate the in-vitro kinase potency of the compounds, they were screened against CDK 2 and CDK9. Kinase assays were performed in 96-well plates u...More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 578nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 193nMAssay Description:Inhibition of CDK7/cyclin H (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 232nMAssay Description:Inhibition of CDK4/cyclin E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Competitive reversible inhibition of CDK2/cyclin E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Competitive reversible inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Competitive reversible inhibition of CDK9/CyclinT (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Displacement of [3H]SR141716 from CB1 receptor in rat cerebellum homogenate at 100 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibitory activity against Escherichia coli TEM-3 Beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMpH: 7.5 T: 30°CAssay Description:To evaluate the in-vitro kinase potency of the compounds, they were screened against CDK 2 and CDK9. Kinase assays were performed in 96-well plates u...More data for this Ligand-Target Pair