BDBM10758 14C-phenylethylamine::2-phenylethan-1-amine::CHEMBL610::phenylethylamine
SMILES NCCc1ccccc1
InChI Key InChIKey=BHHGXPLMPWCGHP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 10758
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University
Curated by PDSP Ki Database
Virginia Commonwealth University
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ketanserin from rat 5HT2A expressed in mouse NIH/3T3 cell membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+4nMAssay Description:Binding affinity against bovine trypsinMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University
Curated by PDSP Ki Database
Virginia Commonwealth University
Curated by PDSP Ki Database
Affinity DataKi: 1.68E+4nMAssay Description:Binding affinity of the compound was performed using [3H]-ketanserin as the radioligand and stably transfected NIH3T3 cells expressing the 5-hydroxyt...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University
Curated by PDSP Ki Database
Virginia Commonwealth University
Curated by PDSP Ki Database
Affinity DataKi: 1.68E+4nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataKi: 1.68E+4nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor expressed NIH3T3 cells using [3H]-ketanserinMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
The University Of Kansas
Curated by ChEMBL
The University Of Kansas
Curated by ChEMBL
Affinity DataKi: 2.20E+5nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
The University Of Kansas
Curated by ChEMBL
The University Of Kansas
Curated by ChEMBL
Affinity DataKi: 4.67E+5nMAssay Description:Inhibitory activity against Norepinephrine N-methyltransferase of bovine adrenal glandsMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
The University Of Kansas
Curated by ChEMBL
The University Of Kansas
Curated by ChEMBL
Affinity DataKi: 8.54E+5nMAssay Description:In vitro inhibitory activity against bovine phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 189nMAssay Description:Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 59nMAssay Description:Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 171nMAssay Description:Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 261nMAssay Description:Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 47nMAssay Description:Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 138nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293T cells assessed as induction of cAMP production by BRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.10E+7nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 120nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Agonist activity at human TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 240nMAssay Description:Agonist activity at rat N-terminal FLAG-tagged TAAR1 expressed in HEK293 cells assessed as [3H]cAMP accumulation measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 6.01E+4nMAssay Description:Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Agonist activity at recombinant human TAAR1 expressed in CHO-K1 cells assessed as increase in intracellular cAMP incubated for 30 mins by HTRF analys...More data for this Ligand-Target Pair
Affinity DataEC50: 106nMAssay Description:Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins usi...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 209nMAssay Description:Activation of rat TAAR1 expressed in Syrian hamster AV12-664 cells assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by...More data for this Ligand-Target Pair
Affinity DataEC50: 129nMAssay Description:Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataEC50: 138nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells coexpressing cAMP BRET biosensor assessed as induction of CAMP production after 20 mins by ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.41E+3nMAssay Description:Inhibitory concentration against human cytochrome P450 2A6More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory concentration against mouse cytochrome P450 2A5More data for this Ligand-Target Pair