BDBM10793 7-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl N-ethyl-N-methylcarbamate::aminotetralin deriv. 28b

SMILES CCN(C)C(=O)Oc1ccc2CCC(Cc2c1)NCC#C

InChI Key InChIKey=LHCNMMLMHAYVJW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10793   

TargetAcetylcholinesterase(Homo sapiens (Human))
Teva Pharmaceutical Industries

LigandPNGBDBM10793(7-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50:  2.04E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Teva Pharmaceutical Industries

LigandPNGBDBM10793(7-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Teva Pharmaceutical Industries

LigandPNGBDBM10793(7-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Teva Pharmaceutical Industries

LigandPNGBDBM10793(7-(prop-2-yn-1-ylamino)-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50:  290nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed