BDBM110947 US8614206, 504::US8614206, 505::US8614206, 506::US8614206, 507

SMILES COC1CCC(CCC1N)c1c(NC(=O)c2nc(sc2N)-c2ccccc2F)cnn1C

InChI Key InChIKey=JEDVVRARJJKKAC-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 110947   

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110947(US8614206, 506 | US8614206, 507 | US8614206, 505 |...)
Affinity DataKi:  0.0550nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110947(US8614206, 506 | US8614206, 507 | US8614206, 505 |...)
Affinity DataKi:  0.197nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110947(US8614206, 506 | US8614206, 507 | US8614206, 505 |...)
Affinity DataKi:  0.392nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM110947(US8614206, 506 | US8614206, 507 | US8614206, 505 |...)
Affinity DataKi:  0.976nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2014
Entry Details
US Patent