BDBM11364 2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfonamido}-N-hydroxypropanamide::Hydroxamate 45::hydroxamate deriv. B24

SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1Cl)C(C)C(=O)NO

InChI Key InChIKey=QTXKDSNGGLBSKK-UHFFFAOYSA-N

Data  11 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 11364   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi:  12nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi:  12nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase ColG(Clostridium histolyticum)
Universita Degli Studi

LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi:  22nMAssay Description:The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase ColG(Clostridium histolyticum)
Universita Degli Studi

LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi:  22nMAssay Description:The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi:  27nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi:  31nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi:  31nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi:  53nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi: >200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi: >200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
Universita Degli Studi

LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataKi: >200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11364(2-{[(2-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Affinity DataIC50:  52nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed