BDBM14009 (20S)-19,20,21,22-Tetrahydro-19-oxo-5H-18,20-ethano-12,14-etheno-6,10-metheno-18H-benz[d]-imidazo[4,3-k][1,6,9,12]oxatriazacyclooctadecosine-9-caronitrile::(5S)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18.6.2.1^{2,5}.1^{14,18}.0^{8,12}.0^{23,27}]triaconta-1(27),8,10,14(29),15,17,20(28),21,23,25-decaene-17-carbonitrile::CHEMBL53821::Macrocyclic 3-Aminopyrrolidinone analog 49

SMILES: O=C1[C@@H]2CCN1c1cccc3ccc(Oc4cc(Cn5cncc5CN2)ccc4C#N)cc13

InChI Key: InChIKey=USPFJPDEADLGIG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14009   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Human)	BDBM14009 ((5S)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18....) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
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Geranylgeranyl transferase type-1 subunit beta [A2V]/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Human)	BDBM14009 ((5S)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18....) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Human)	BDBM14009 ((5S)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18....) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM14009 ((5S)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18....) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair