BDBM14170 APC-7377::Benzo[b]thiophene-2-carboxamidine::[amino(1-benzothiophen-2-yl)methylidene]azanium

SMILES NC(=[NH2+])c1cc2ccccc2s1

InChI Key InChIKey=JZWDLUGQTRKBNA-UHFFFAOYSA-O

Data  6 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14170   

TargetSerine protease 1(Bos taurus (bovine))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)
Affinity DataKi:  1.00E+3nM ΔG°:  -8.10kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)
Affinity DataKi:  2.30E+3nM ΔG°:  -7.61kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)
Affinity DataKi:  9.90E+3nM ΔG°:  -6.75kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)
Affinity DataKi:  1.50E+4nM ΔG°:  -6.51kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)
Affinity DataKi:  2.10E+4nM ΔG°:  -6.31kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)
Affinity DataKi:  5.80E+4nM ΔG°:  -5.72kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed