BDBM14245 4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-carboxylic acid::CHEMBL213758::Monocyclic thiophene analog 11

SMILES OC(=O)COc1c(Br)c(sc1C(O)=O)-c1ccccc1

InChI Key InChIKey=MVDWLRCTJUXCCB-UHFFFAOYSA-N

Data  10 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 14245   

TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14245(4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-car...)
Affinity DataKi:  320nM ΔG°:  -8.85kcal/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14245(4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-car...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14245(4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-car...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of PTPN1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14245(4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-car...)
Affinity DataKi:  3.20E+3nM ΔG°:  -7.42kcal/molepH: 7.0 T: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14245(4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-car...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14245(4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-car...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of PTPN2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM14245(4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-car...)
Affinity DataKi:  2.80E+5nMAssay Description:Inhibition of human recombinant CD45More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM14245(4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-car...)
Affinity DataKi:  2.80E+5nMAssay Description:Inhibition of PTPRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14245(4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-car...)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of PTPRFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14245(4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-car...)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human recombinant LARMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed