BDBM14364 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine::3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-N-ethyl-8-(propan-2-yl)-3H-purin-6-amine::V11294

SMILES CCNc1ncn(Cc2ccc(OC)c(OC3CCCC3)c2)c2nc(nc12)C(C)C

InChI Key InChIKey=CGFRGBQJWVFTRF-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14364   

LigandPNGBDBM14364(3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-N-e...)
Affinity DataKi:  141nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14364(3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-N-e...)
Affinity DataKi:  172nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14364(3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-N-e...)
Affinity DataKi:  270nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14364(3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-N-e...)
Affinity DataKi:  2.89E+3nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14364(3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-N-e...)
Affinity DataKi:  3.90E+3nM ΔG°:  -7.30kcal/molepH: 8.0 T: 2°CAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed