BDBM14826 1-[5-chloro-2-(tetrahydrofuran-3-yloxy)phenyl]-3-(5-cyanopyrazin-2-yl)urea::3-[5-chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)urea::Chk1_12::urea-based inhibitor 2a

SMILES: Clc1ccc(OC2CCOC2)c(NC(=O)Nc2cnc(cn2)C#N)c1

InChI Key: InChIKey=YPNTXIYIFCQOMG-UHFFFAOYSA-N

Data: 2 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14826   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Human)	BDBM14826 (3-[5-chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM14826 (3-[5-chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM14826 (3-[5-chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 [2-280] (Human)	BDBM14826 (3-[5-chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopy...) Show SMILES Show InChI	GoogleScholar	UniChem		2.95	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM14826 (3-[5-chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopy...) Show SMILES Show InChI	GoogleScholar	UniChem		3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair