BDBM14827 (+/-)1-[5-Chloro-2-(tetrahydro-pyran-4-yloxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea::3-[5-chloro-2-(oxan-4-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)urea::urea-based inhibitor 2b

SMILES: Clc1ccc(OC2CCOCC2)c(NC(=O)Nc2cnc(cn2)C#N)c1

InChI Key: InChIKey=GELSSERXHLOALO-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14827   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Human)	BDBM14827 ((+/-)1-[5-Chloro-2-(tetrahydro-pyran-4-yloxy)-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
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