BDBM16093 2-[(biphenyl-4-ylcarbonyl)(methyl)amino]benzoic acid::2-[methyl(4-phenylbenzene)amido]benzoic acid::Inhibitor 1

SMILES CN(C(=O)c1ccc(cc1)-c1ccccc1)c1ccccc1C(O)=O

InChI Key InChIKey=GYBOIDMCHWKXRL-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16093   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University Of Leeds

LigandPNGBDBM16093(2-[(biphenyl-4-ylcarbonyl)(methyl)amino]benzoic ac...)
Affinity DataKi:  4.90E+3nM ΔG°:  -7.24kcal/mole IC50:  4.26E+4nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University Of Leeds

LigandPNGBDBM16093(2-[(biphenyl-4-ylcarbonyl)(methyl)amino]benzoic ac...)
Affinity DataIC50:  4.27E+4nMAssay Description:Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectr...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Leeds

LigandPNGBDBM16093(2-[(biphenyl-4-ylcarbonyl)(methyl)amino]benzoic ac...)
Affinity DataIC50: >2.00E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed