BDBM171962 US9085584, 104::US9085584, 104a::US9085584, 104b

SMILES Cc1ccc(cc1-c1nnc2c(C)nc3ccc(nc3n12)C1CC1)C1(O)CCOCC1O

InChI Key InChIKey=CYFNFWBPQBWVDR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 171962   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM171962(US9085584, 104a | US9085584, 104b | US9085584, 104)
Affinity DataIC50: 30nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM171962(US9085584, 104a | US9085584, 104b | US9085584, 104)
Affinity DataIC50: 36nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM171962(US9085584, 104a | US9085584, 104b | US9085584, 104)
Affinity DataIC50: 40nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM171962(US9085584, 104a | US9085584, 104b | US9085584, 104)
Affinity DataIC50: 3.23E+3nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM171962(US9085584, 104a | US9085584, 104b | US9085584, 104)
Affinity DataIC50: 7.72E+3nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM171962(US9085584, 104a | US9085584, 104b | US9085584, 104)
Affinity DataIC50: 9.77E+3nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent