BDBM179948 US9133148, 2l

SMILES FC(F)(F)C(OC(=O)N1CCN(CC1)C(c1cccnc1)c1cccnc1)C(F)(F)F

InChI Key InChIKey=AJHFORZUQMIBMQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 179948   

TargetMonoglyceride lipase(Human)
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM179948(US9133148, 2l)
Affinity DataIC50: 3nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM179948(US9133148, 2l)
Affinity DataIC50: 26nMAssay Description:Inhibition of PLA2G7 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMonoacylglycerol lipase ABHD6(Human)
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM179948(US9133148, 2l)
Affinity DataIC50: 182nMAssay Description:Inhibition of ABHD6 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Mouse)
The Scripps Research Institute

US Patent
LigandPNGBDBM179948(US9133148, 2l)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 uL, 1.0 mg/mL total protein concentration) were preincubated with varying concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent