BDBM18129 (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid::L-[U-14C]Tyr::Tyrosine::US11021454, Compound L-tyr

SMILES N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI Key InChIKey=OUYCCCASQSFEME-QMMMGPOBSA-N

Data  1 KI  2 IC50

PDB links: 23 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 18129   

TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Binghamton University

LigandPNGBDBM18129((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...)
Affinity DataKi:  2.50E+4nM ΔG°:  -6.53kcal/molepH: 6.8 T: 2°CAssay Description:Inhibition of [3H]-L-tyrosine incorporation into tubulin by enzyme tubulin tyrosine ligase (TTL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
China Pharmaceutical University

US Patent
LigandPNGBDBM18129((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...)
Affinity DataIC50: >6.00E+4nMAssay Description:11.1 Preparation of Reagents and Standard Solutions(1) 75 mM phosphate buffer (PB, pH 7.4): containing KH2PO4 0.0956 g, K2HPO4 0.6946 g, EDTA 1.862 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM18129((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...)
Affinity DataIC50:  6.80E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed