BDBM189644 US9174982, 210::US9174982, 211

SMILES COC1CCC(COc2ncc(cc2Cl)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(Cl)cc3)CC2)CC1

InChI Key InChIKey=UQJOQWQMMPNGKT-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 189644   

TargetApoptosis regulator Bcl-2(Human)
Abbvie

US Patent
LigandPNGBDBM189644(US9174982, 210 | US9174982, 211)
Affinity DataKi:  0.0110nM ΔG°:  -14.9kcal/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Abbvie

US Patent
LigandPNGBDBM189644(US9174982, 210 | US9174982, 211)
Affinity DataKi:  0.0580nM ΔG°:  -14.0kcal/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent