BDBM206112 US9255110, 25::US9255110, 26::US9255110, 27::US9255110, 31

SMILES NCC1CCN(CC1)c1ccc(Cl)cc1NC(=O)c1cnn2cccnc12

InChI Key InChIKey=ITDPQZHRPNERLI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 206112   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 31 | US9255110, 27 | US...)
Affinity DataIC50: 31nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 31 | US9255110, 27 | US...)
Affinity DataIC50: 31nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 31 | US9255110, 27 | US...)
Affinity DataIC50: 31nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 31 | US9255110, 27 | US...)
Affinity DataIC50: 37nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 31 | US9255110, 27 | US...)
Affinity DataIC50: 463nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 31 | US9255110, 27 | US...)
Affinity DataIC50: 725nMpH: 7.2 T: 2°CAssay Description:SYK activity is measured by phosphorylation of a peptide substrate (Biotin-EPEGDYEEVLE) with [gamma-33P] ATP. The enzyme reaction was conducted at 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 31 | US9255110, 27 | US...)
Affinity DataIC50: 920nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
US Patent