BDBM208267 US9265773, 2
SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
InChI Key InChIKey=GOHCXBUFLQKEIO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 22 hits for monomerid = 208267
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 1.60nMAssay Description:Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 1nMAssay Description:Non-nucleoside inhibition of NS5B polymerase S365A mutant in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 7.30nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2A infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 3.90nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2B infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 3A infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 4A infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 2.70nMAssay Description:Inhibition of NS5B polymerase C316Y mutant in HCV genotype 1A infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Inhibition of NS5B polymerase S365A mutant in HCV genotype 1A infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Inhibition of NS5B polymerase E1202G/T1280I/S2197P mutant in HCV genotype 2a infected in human HuH7 replicon cells after 72 hrs in presence of 10% FB...More data for this Ligand-Target Pair
Affinity DataEC50: 2.20nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Inhibition of NS5B polymerase E1202G/T1280I/S2197P mutant in HCV genotype 1a infected in human HuH7 replicon cells after 72 hrs in presence of 10% FB...More data for this Ligand-Target Pair
Affinity DataEC50: 2.70nMAssay Description:Inhibition of NS5B polymerase E1202G/T1280I/S2197P mutant in HCV genotype 1b infected in human HuH7 replicon cells after 72 hrs in presence of 10% FB...More data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Inhibition of NS5B polymerase E1202G/T1280I/S2197P mutant in HCV genotype 1b infected in human HuH7 replicon cells after 72 hrs in presence of 50% hu...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 2.20nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 1b by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 7.30nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 2a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 3.90nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 2b by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 3a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 4a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 2.30nMAssay Description:Non-nucleoside inhibition of NS5B polymerase C316Y mutant in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...More data for this Ligand-Target Pair