BDBM2121 1-(5-chloropyridin-2-yl)-3-{2-[3-(dimethylamino)-2,6-difluorophenyl]ethyl}thiourea::LY300046HCl Analog 5::N-[2-(2,6-Difluoro-3-(dimethylamino)phenethyl)]-N-[2-(5-chloropyridyl)]thiourea::PETT deriv.

SMILES CN(C)c1ccc(F)c(CCNC(=S)Nc2ccc(Cl)cn2)c1F

InChI Key InChIKey=JFMKEUCKWUZCOC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2121   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2121(1-(5-chloropyridin-2-yl)-3-{2-[3-(dimethylamino)-2...)
Affinity DataIC50:  8nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2121(1-(5-chloropyridin-2-yl)-3-{2-[3-(dimethylamino)-2...)
Affinity DataIC50:  190nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2121(1-(5-chloropyridin-2-yl)-3-{2-[3-(dimethylamino)-2...)
Affinity DataIC50:  1.90E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed