BDBM212860 US9278960, 2-7::US9663506, Example 2-7
SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3C(=O)CCC3=O)cc2n1
InChI Key InChIKey=XSTBUOHORFUCIB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 212860
TargetGuanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 9nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+6nMAssay Description:Modulating activity at PXR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Negative allosteric modulation of rat mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Negative allosteric modulation of human mGluR2 by GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Negative allosteric modulation of rat mGluR2 by GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR1 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR3 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR4 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR7 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR8 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.22E+3nMAssay Description:Antagonist activity at mGluR6 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+7nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair