BDBM212860 US9278960, 2-7::US9663506, Example 2-7

SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3C(=O)CCC3=O)cc2n1

InChI Key InChIKey=XSTBUOHORFUCIB-UHFFFAOYSA-N

Data  15 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 212860   

LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50:  9nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataEC50:  1.10E+6nMAssay Description:Modulating activity at PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50:  9nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50:  9nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50:  8.90nMAssay Description:Negative allosteric modulation of rat mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50:  20nMAssay Description:Negative allosteric modulation of human mGluR2 by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50:  54nMAssay Description:Negative allosteric modulation of rat mGluR2 by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR1 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR3 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR4 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR7 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR8 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50:  9.22E+3nMAssay Description:Antagonist activity at mGluR6 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: >5.00E+7nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50:  9nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In DepthDetails US Patent