BDBM21961 (2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)pentanamido]pyrrolidine-2-carboxamide::CHEMBL228077::JMC522060 Compound 3::N omega-Nitro-L-Arginine-Containing Dipeptide, 2

SMILES N[C@@H](CCCN=C(N)N[N+]([O-])=O)C(=O)N[C@H]1CN[C@@H](C1)C(N)=O

InChI Key InChIKey=IUFRDGFKAVLPFZ-CSMHCCOUSA-N

Data  14 KI

PDB links: 6 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 21961   

TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  100nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
University Of California Irvine

LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  100nM ΔG°:  -9.70kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
University Of California Irvine

LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  100nM ΔG°:  -9.70kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
University Of California Irvine

LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  100nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
University Of California Irvine

LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  330nM ΔG°:  -8.98kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
University Of California Irvine

LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  330nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial [N368D](Bos taurus (bovine))
University Of California Irvine

LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  5.10E+3nM ΔG°:  -7.34kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  1.70E+4nM ΔG°:  -6.61kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain [D597N](Rattus norvegicus (rat))
University Of California Irvine

LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  2.10E+4nM ΔG°:  -6.48kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  7.20E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  7.20E+4nM ΔG°:  -5.74kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  1.10E+5nM ΔG°:  -5.49kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  1.10E+5nM ΔG°:  -5.49kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair