BDBM22372 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol::4-[(2S,3R)-3-[(3,4-dihydroxyphenyl)methyl]-2-methylbutyl]benzene-1,2-diol::CHEMBL313972::Masoprocol::NDGA::Nordihydroguaiaretic Acid
SMILES C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1
InChI Key InChIKey=HCZKYJDFEPMADG-TXEJJXNPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 37 hits for monomerid = 22372
Affinity DataIC50: >1.00E+4nMAssay Description:The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ici Pharmaceuticals Group
Curated by ChEMBL
Ici Pharmaceuticals Group
Curated by ChEMBL
Affinity DataEC50: >3.30E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:In vitro inhibition of Prostaglandin G/H synthase in BSV cell line.More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity of the compound against human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibitory activity of the compound against rat basophilic leukemia cell 5-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibitory activity against rabbit reticulocyte 15-lipoxygenase was evaluated by measuring inhibition of the conversion of linoleic acid to hydropero...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ici Pharmaceuticals Group
Curated by ChEMBL
Ici Pharmaceuticals Group
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human 15-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of human platelet-type 12-lipoxygenaseMore data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Alexander Technological Education Institute Of Thessaloniki
Curated by ChEMBL
Alexander Technological Education Institute Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 3.13E+4nMAssay Description:Inhibition of soybean LOX type 1 pre-incubated for 4 mins at 7x10'-7 w/v concentration assessed as inhibition of sodium linoleate to 13-hydroperoxyli...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ici Pharmaceuticals Group
Curated by ChEMBL
Ici Pharmaceuticals Group
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human 5-LOX in human PBML assessed as inhibition of A23187-induced LTB4 production preincubated for 15 mins measured after ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ici Pharmaceuticals Group
Curated by ChEMBL
Ici Pharmaceuticals Group
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human 5-LOX in human peripheral blood mononuclear leukocytes assessed as inhibition of calymycin A23187-stimulated LTB4 production prei...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Universiti Putra Malaysia
Curated by ChEMBL
Universiti Putra Malaysia
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:In vitro inhibition of RBL-1 5-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:In vitro inhibitory activity against RBL-1 5-LOMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in rat bloodMore data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Alexander Technological Education Institute Of Thessaloniki
Curated by ChEMBL
Alexander Technological Education Institute Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibitory activity against soybean 1-lipoxygenase (SLO)More data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibitory activity against human platelet 12-lipoxygenase (12-HLO)More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against human reticulocyte 15-lipoxygenase (15-HLO)More data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Alexander Technological Education Institute Of Thessaloniki
Curated by ChEMBL
Alexander Technological Education Institute Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:In vitro inhibitory activity against 15-lipoxygenase obtained from soybeanMore data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Alexander Technological Education Institute Of Thessaloniki
Curated by ChEMBL
Alexander Technological Education Institute Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase obtained from potatoMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
San Francisco State University
Curated by ChEMBL
San Francisco State University
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of 15 LOXMore data for this Ligand-Target Pair
Affinity DataIC50: 3.88E+4nMAssay Description:Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric ana...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]DHT from human androgen receptor expressed in Escherichia coli BL21 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Displacement of 5-iodoacetamidofluorescein labeled SRC23 peptide CKENALLRYLLDKDD human androgen receptor AF2 site expressed in Escherichia coli BL21 ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human placental microsome CYP19More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of His-tagged human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of His-tagged human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro inhibition of LTB4 production was measured in rat bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human platelet N-terminal His6-tagged 12-lipoxygenase by UV-vis spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human reticulocyte N-terminal His6-tagged 15-lipoxygenase by UV-vis spectrometryMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ici Pharmaceuticals Group
Curated by ChEMBL
Ici Pharmaceuticals Group
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human N-terminal His6-tagged 5-lipoxygenase arachidonic acid by UV-vis spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:In vitro inhibition of PGE-2 production was measured in rat bloodMore data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Alexander Technological Education Institute Of Thessaloniki
Curated by ChEMBL
Alexander Technological Education Institute Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen...More data for this Ligand-Target Pair