BDBM22872 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methyl-piperazine;maleate::1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine::1-{6-chloro-2-thiatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-9-yl}-4-methylpiperazine::CHEMBL64249::CLOROTEPINE (+)::CLOROTEPINE(-)::Clothepin::OCTOCLOTHEPIN,(+)::OCTOCLOTHEPIN,(-)::Octoclothepin::Octoclothepine

SMILES: CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12

InChI Key: InChIKey=XRYLGRGAWQSVQW-UHFFFAOYSA-N

Data: 27 KI  8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 22872   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ubiquitin-conjugating enzyme E2 N (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium channel subfamily K member 9 (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium channel subfamily K member 9 (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
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Serotonin 2 (5-HT2) receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
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D(1A) dopamine receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
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D(2) dopamine receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
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Histamine H1 receptor (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(3) dopamine receptor (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
D(2) dopamine receptor (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 7 (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(4) dopamine receptor (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 6 (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1B adrenergic receptor (Golden hamster)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2C (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.570	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1A adrenergic receptor (Bovine)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.660	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
D(2) dopamine receptor (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.670	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1D adrenergic receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.770	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(3) dopamine receptor (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.58	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 6 (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 7 (Guinea pig)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Rat)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		17.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Guinea pig)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		32.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Trace amine-associated receptor 1 (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		493	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Histamine H4 receptor (Human)	BDBM22872 (1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	>-7.09	n/a	n/a	n/a	n/a	n/a	7.4	37
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