BDBM22955 4-methoxyphenyl 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate::CHEMBL316866::Indomethacin derivative, 8

SMILES COc1ccc(OC(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)cc1

InChI Key InChIKey=RZUDCMGEWDZMRH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 22955   

TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine

LigandPNGBDBM22955(4-methoxyphenyl 2-{1-[(4-chlorophenyl)carbonyl]-5-...)
Affinity DataIC50: >6.60E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

LigandPNGBDBM22955(4-methoxyphenyl 2-{1-[(4-chlorophenyl)carbonyl]-5-...)
Affinity DataIC50:  40nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

LigandPNGBDBM22955(4-methoxyphenyl 2-{1-[(4-chlorophenyl)carbonyl]-5-...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using [14C]-AA (50 uM) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine

LigandPNGBDBM22955(4-methoxyphenyl 2-{1-[(4-chlorophenyl)carbonyl]-5-...)
Affinity DataIC50: >6.60E+4nMAssay Description:In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]AA (50 uM) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine

LigandPNGBDBM22955(4-methoxyphenyl 2-{1-[(4-chlorophenyl)carbonyl]-5-...)
Affinity DataIC50:  50nMT: 2°CAssay Description:Inhibition assays in triplicate were performed by preincubating enzyme (60-80 nM) and inhibitors (0-5 mM) for 20 min at 25°C followed by the add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed