BDBM238524 US9394297, 156::US9394297, 160::US9394297, 161

SMILES Cc1nc2cccc(-c3cc4c([nH]3)C(C)CNC4=O)c2nc1F

InChI Key InChIKey=UAYKLVYFPJYTBE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 238524   

TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 238524BDBM238524(US9394297, 161 | US9394297, 160 | US9394297, 156)
Affinity DataIC50: 0.5nMpH: 7.0 T: 2°CAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 238524BDBM238524(US9394297, 161 | US9394297, 160 | US9394297, 156)
Affinity DataIC50: 0.700nMpH: 7.0 T: 2°CAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 238524BDBM238524(US9394297, 161 | US9394297, 160 | US9394297, 156)
Affinity DataIC50: 0.800nMpH: 7.0 T: 2°CAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 238524BDBM238524(US9394297, 161 | US9394297, 160 | US9394297, 156)
Affinity DataIC50: 1nMpH: 7.0 T: 2°CAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 238524BDBM238524(US9394297, 161 | US9394297, 160 | US9394297, 156)
Affinity DataIC50: 526nMpH: 7.0 T: 2°CAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 238524BDBM238524(US9394297, 161 | US9394297, 160 | US9394297, 156)
Affinity DataIC50: 758nMpH: 7.0 T: 2°CAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
US Patent