BDBM244209 (s)-n-(2-(dimethylamino)-1-phenylethyl)-5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 148::US9546173, cmpd 168

SMILES CN(C)CC(NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C)c1ccccc1

InChI Key InChIKey=QDIMOURDMVMOHZ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 244209   

TargetRibosomal protein S6 kinase alpha-3(Human)
Novartis

US Patent
LigandPNGBDBM244209(US9546173, cmpd 168 | (s)-n-(2-(dimethylamino)-1-p...)
Affinity DataIC50: 86nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-1(Human)
Novartis

US Patent
LigandPNGBDBM244209(US9546173, cmpd 168 | (s)-n-(2-(dimethylamino)-1-p...)
Affinity DataIC50: 94nMAssay Description:Lists compounds that were tested for inhibition of RSK; the IC50 values are in micromolar units, and refer to inhibition of RSK1 and RSK2, respective...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Novartis

US Patent
LigandPNGBDBM244209(US9546173, cmpd 168 | (s)-n-(2-(dimethylamino)-1-p...)
Affinity DataIC50: 96nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Novartis

US Patent
LigandPNGBDBM244209(US9546173, cmpd 168 | (s)-n-(2-(dimethylamino)-1-p...)
Affinity DataIC50: 112nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandPNGBDBM244209(US9546173, cmpd 168 | (s)-n-(2-(dimethylamino)-1-p...)
Affinity DataIC50: 448nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Novartis

US Patent
LigandPNGBDBM244209(US9546173, cmpd 168 | (s)-n-(2-(dimethylamino)-1-p...)
Affinity DataIC50: 461nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-1(Human)
Novartis

US Patent
LigandPNGBDBM244209(US9546173, cmpd 168 | (s)-n-(2-(dimethylamino)-1-p...)
Affinity DataIC50: 1.77E+4nMAssay Description:Lists compounds that were tested for inhibition of RSK; the IC50 values are in micromolar units, and refer to inhibition of RSK1 and RSK2, respective...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Novartis

US Patent
LigandPNGBDBM244209(US9546173, cmpd 168 | (s)-n-(2-(dimethylamino)-1-p...)
Affinity DataIC50: 2.02E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandPNGBDBM244209(US9546173, cmpd 168 | (s)-n-(2-(dimethylamino)-1-p...)
Affinity DataIC50: 1.25E+5nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent