BDBM244212 (5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyrimidin-6(7h)-yl)(4-methylpiperazin-1-yl)methanone::US9546173, cmpd 151

SMILES CN1CCN(CC1)C(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C

InChI Key InChIKey=FLSBFSZAHVORFU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 244212   

TargetRibosomal protein S6 kinase alpha-3(Human)
Novartis

US Patent
LigandPNGBDBM244212((5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyr...)
Affinity DataIC50: 1.17E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-1(Human)
Novartis

US Patent
LigandPNGBDBM244212((5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyr...)
Affinity DataIC50: 1.61E+3nMAssay Description:Lists compounds that were tested for inhibition of RSK; the IC50 values are in micromolar units, and refer to inhibition of RSK1 and RSK2, respective...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandPNGBDBM244212((5,5-dimethyl-2-(phenylamino)-5h-pyrrolo[3,4-d]pyr...)
Affinity DataIC50: 5.57E+3nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent