BDBM246881 US10053465, 20::US10065963, Compound 20::US10125150, Example 20::US10336759, # 20::US10479803, Example 20::US10519163, Example 20::US10675284, Example 20::US11084822, Example 20::US11130767, # 20::US11136326, Example 20::US11304949, Compound 20::US11324749, Comp. No. 20::US11406640, Comp. No. 20::US11596632, Comp. No. 20::US11918581, Compound 20::US11957661, Compound 20::US11992490, Compound 20::US20240058343, Compound 20::US20240307353, Compound 20::{1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trifluoromethyl) pyridin-2- yl]oxy}cyclohexyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]azetidin-3- yl}aceionitrile

SMILES: CC(C)(O)c1cc(O[C@H]2CC[C@H](CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F

InChI Key: InChIKey=JKMHKJRBEGMJBK-UHFFFAOYSA-N

Data: 30 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 246881   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	7.8	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM246881 ({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair