BDBM250748 US9452986, 52
SMILES F[C@@H]1CCN(C1)C(=O)c1ccc2cc(Oc3ccc(cn3)C(F)(F)F)ccc2n1
InChI Key InChIKey=FWLFRXVPNVBXGR-CQSZACIVSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 250748
Affinity DataIC50: 2.98E+3nMT: 37°CAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.85E+3nMT: 37°CAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.8 (Essen, Ann Arbor, Mich.) were quickly thawed and pl...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant human Nav 1.7 expressed in HEK293F cells incubated for 3 mins by FRET based membrane potential assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.55E+4nMAssay Description:Inhibition of hERG channel by electrophysiologyMore data for this Ligand-Target Pair
Affinity DataIC50: 5.94E+3nMAssay Description:Inhibition of human Nav 1.8 by manual electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Nav 1.5 expressed in HEK293 cells at -90 mV holding potential by Whole cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human Nav1.8 by FRET based membrane potential assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human Nav 1.7 expressed in HEK293F cells at -65 to 80 mV holding potential by manual voltage clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of recombinant human Nav 1.7 expressed in HEK293F cells at -65 mV holding potential by Qpatch clamp electrophysiology methodMore data for this Ligand-Target Pair