BDBM259407 US10457647, Example 6::US11180460, Example 6::US11673868, Example 6::US9512084, 6

SMILES CN(CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(cc2F)C2CC2)c1C)C(=O)C=C

InChI Key InChIKey=CUABMPOJOBCXJI-UHFFFAOYSA-N

Data  12 IC50  18 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 259407   

TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  1nMpH: 7.5 T: 30°CAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPhosphatidylinositol 4-kinase beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of PIK4CB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of BTK in vitamin D3 differentiated human THP1 cells assessed as inhibition of FCgammaR-induced IL8 production measured after 24 hrs by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  18nMAssay Description:Inhibition of BTK in human B cells assessed as reduction in anti-IgM/IL4-stimulated CD69 expression on B cells preincubated for 60 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataEC50: >5.48E+3nMAssay Description:Transactivation of PXR (unknown origin) assessed as induction of CYP3A activity by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  0.630nMAssay Description:Binding affinity to DNA-tagged recombinant BTK (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to DNA-tagged recombinant ITK (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to DNA-tagged recombinant EGFR (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to DNA-tagged recombinant ERBB2 (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  67nMAssay Description:Inhibition of BTK in human basophils assessed as reduction in anti-IgE mouse IgG1 antibody Le2-stimulated CD63 expression on basophil preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human ERG by Qpatch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  540nMAssay Description:Binding affinity to DNA-tagged recombinant BMX (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  110nMAssay Description:Binding affinity to DNA-tagged recombinant TEC (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to DNA-tagged recombinant JAK3 (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to DNA-tagged recombinant ERBB4 (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to ERBB2 (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to ERBB4 (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Blk(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to BLK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to BMX (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  0.240nMAssay Description:Binding affinity to BTK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to EGFR (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to ITK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  1.90E+4nMAssay Description:Binding affinity to JAK3 (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Tec(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  77nMAssay Description:Binding affinity to TEC (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase TXK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to TXK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
In DepthDetails US Patent