BDBM264229 (2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin- 1-yl)butanamide::US10167276, Example 49::US10654835, Example 49::US11247983, Example 49::US9714236, 49

SMILES: CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F

InChI Key: InChIKey=RWZJXPSNVCNPSC-UHFFFAOYSA-N

Data: 16 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 264229   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	7.3	n/a
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Tyrosine-protein kinase JAK2 [831-1132] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.77E+3	n/a	n/a	n/a	n/a	7.3	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	7.3	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [831-1132] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [831-1132] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM264229 ((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair