BDBM26455 (2R)-2-({6-[(4-cyano-2-fluorophenyl)methoxy]naphthalene-2-}sulfonamido)pentanedioic acid::MurD inhibitor (compound 40)::naphthalene-N-sulfonyl-D-glu derivative, 17n

SMILES OC(=O)CC[C@@H](NS(=O)(=O)c1ccc2cc(OCc3ccc(cc3F)C#N)ccc2c1)C(O)=O

InChI Key InChIKey=IRJUSGUHNFMVCK-OAQYLSRUSA-N

Data  2 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26455   

TargetUDP-N-acetylmuramoylalanine--D-glutamate ligase(Escherichia coli (strain K12))
Lek Pharmaceuticals

LigandPNGBDBM26455((2R)-2-({6-[(4-cyano-2-fluorophenyl)methoxy]naphth...)
Affinity DataIC50:  8.50E+4nMpH: 8.6 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the addition of D-[14C]Glu to UMA. The radioactive substrate and product were separated by re...More data for this Ligand-Target Pair
TargetUDP-N-acetylmuramoylalanine--D-glutamate ligase(Escherichia coli (strain K12))
Lek Pharmaceuticals

LigandPNGBDBM26455((2R)-2-({6-[(4-cyano-2-fluorophenyl)methoxy]naphth...)
Affinity DataIC50:  8.50E+4nMMore data for this Ligand-Target Pair
TargetUDP-N-acetylmuramoylalanine--D-glutamate ligase(Escherichia coli (strain K12))
Lek Pharmaceuticals

LigandPNGBDBM26455((2R)-2-({6-[(4-cyano-2-fluorophenyl)methoxy]naphth...)
Affinity DataKd:  5.50E+3nMAssay Description:Binding affinity to 6x His-tagged and 15N/13C-labeled Escherichia coli MurD ligase measured at NMR signal 56 by 1H/13C-HSQC 2D NMR spectroscopyMore data for this Ligand-Target Pair
TargetUDP-N-acetylmuramoylalanine--D-glutamate ligase(Escherichia coli (strain K12))
Lek Pharmaceuticals

LigandPNGBDBM26455((2R)-2-({6-[(4-cyano-2-fluorophenyl)methoxy]naphth...)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to 6x His-tagged and 15N/13C-labeled Escherichia coli MurD ligase measured at NMR signal 13 by 1H/13C-HSQC 2D NMR spectroscopyMore data for this Ligand-Target Pair
TargetUDP-N-acetylmuramoylalanine--D-glutamate ligase(Escherichia coli (strain K12))
Lek Pharmaceuticals

LigandPNGBDBM26455((2R)-2-({6-[(4-cyano-2-fluorophenyl)methoxy]naphth...)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to 6x His-tagged and 15N/13C-labeled Escherichia coli MurD ligase measured at NMR signal 9 by 1H/13C-HSQC 2D NMR spectroscopyMore data for this Ligand-Target Pair