BDBM270575 (S)-3-((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)((4- (neopentylamino) quinazolin-6- yl)amino)methyl- d)benzonitrile::US10059695, I-7::US10577352, Compound I-7

SMILES CC(C)(C)CNc1ncnc2ccc(NC(c3cn(nn3)C3CC3)c3cccc(c3)C#N)cc12

InChI Key InChIKey=HZPQSSSEUZOMMO-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270575   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270575((S)-3-((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)((4...)
Affinity DataIC50:  2.60nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270575((S)-3-((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)((4...)
Affinity DataEC50:  102nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270575((S)-3-((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)((4...)
Affinity DataIC50:  2.60nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270575((S)-3-((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)((4...)
Affinity DataEC50:  102nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent