BDBM271626 US10065941, Compound I-127::US9732060, Compound I-127

SMILES C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O

InChI Key

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 271626   

TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50:  4nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50:  4nMAssay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50:  4.20nMAssay Description:Antagonist activity at P2X3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 3(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at rat P2X3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at P2X1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at P2X2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50:  4.20nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 7(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at P2X7 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 1A2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP2X purinoceptor 4(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at P2X4 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed