BDBM27759 N-(2-hydroxy-5-phenylphenyl)-4-{[(2-methylpropyl)amino]methyl}benzamide::US9096559, 73::aminophenol analogue, 7

SMILES CC(C)CNCc1ccc(cc1)C(=O)Nc1cc(ccc1O)-c1ccccc1

InChI Key InChIKey=YLMXYRPQVCWEQW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27759   

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM27759(N-(2-hydroxy-5-phenylphenyl)-4-{[(2-methylpropyl)a...)
Affinity DataIC50: 110nMAssay Description:Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme sou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM27759(N-(2-hydroxy-5-phenylphenyl)-4-{[(2-methylpropyl)a...)
Affinity DataIC50: 112nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2009
Entry Details Article
PubMed