BDBM279107 5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 138::US10034861, Example 139::US10512632, Example 139::US10766893, Example S139::US10806718, Example 139::US11026923, Example 139::US11491140, Example 139::US11634416, Example 139

SMILES CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(ncc2n1)C(C)CC

InChI Key InChIKey=BIQGCKNODPBTSC-UHFFFAOYSA-N

Data  42 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 279107   

LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  93nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  530nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  180nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  330nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  35nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  530nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  93nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  6.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  180nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  330nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  35nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  530nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  93nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  6.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  180nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  330nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  35nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  530nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  93nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  6.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  180nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  330nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  35nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  530nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  93nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  6.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  180nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  330nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  35nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  530nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  93nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  6.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  180nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  330nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  35nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  530nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  93nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  6.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  180nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  330nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  35nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279107(5-(2-ethoxy-3-pyridyl)-N-[(5-methyl-1,3,4-oxadiazo...)
Affinity DataIC50:  6.80nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent