BDBM280349 (S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamino)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide::US10030004, Compound 16a::US10501436, Compound 16a::US11053216, Compound 16a::US11702401, Compound 16a

SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1N(C)C)-c1cc(Cl)ccc1F

InChI Key InChIKey=SRVVCPDKVNJPAH-ZDUSSCGKSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280349   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  7.30E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  114nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  42.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Mus musculus (Mouse))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  7.30E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  114nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  42.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sid

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  7.30E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  114nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  42.2nMMore data for this Ligand-Target Pair

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TargetBone morphogenetic protein 10(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  7.30E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  114nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50:  42.2nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280349((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamin...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
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