BDBM280822 (S)-2-(3-(4-{4-amino-2- [1-(2-fluorobenzyl)-1H- pyrazolo[3,4-b]pyridin-3- yl]-5-methyl-6-oxo-6,7- dihydro-5H-pyrrolo[2,3- d]pyrimidin-5- yl}phenyl)propanamido)- 2-methylpropanoic acid::US10030027, Example 101B::US10428076, Example 101B
SMILES CC(C)(NC(=O)CCc1ccc(cc1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)C(O)=O
InChI Key InChIKey=YBLBWRSHGIHCBF-XIFFEERXSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 280822
TargetGuanylate cyclase soluble subunit alpha-1/beta-1(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataKi: 0.0260nMAssay Description:The binding buffer was composed of 50 mM triethanolamine, pH 7.4, 3 mM MgCl2, 0.025% BSA, 2 mM dithiothreitol (DTT), 300 μM DETA/NO and 400 _...More data for this Ligand-Target Pair
Affinity DataKi: 0.0260nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair