BindingDB PrimarySearch_ki

Search and Browse
- Target
- Compound
- Special tools
- Citation
- Special Data Sets
- Other Databases
  - PDB 85% 100% Seq ID
  - UniProtKB/Swiss-Prot
  - UniProtKB/TrEMBL
  - PubMed
Download
- All Compounds & Data
- Target Names &
  - Ki IC50 Kd EC50
  - ΔG° ΔH° -TΔS°
Enter Data

BDBM281311 4-(4-{[2-(biphenyl-4-yl)ethyl]amino}-1H-pyrazolo[4,3-c]pyridin-6-::US10022376, Example 124

SMILES: CCc1cc(O)ccc1-c1cc2[nH]ncc2c(NCCc2ccc(cc2)-c2ccccc2)n1

InChI Key: InChIKey=IBABGXODAYRWFA-UHFFFAOYSA-N

Data: 4 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 281311
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Human)	BDBM281311 (4-(4-{[2-(biphenyl-4-yl)ethyl]amino}-1H-pyrazolo[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	87.6	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM281311 (4-(4-{[2-(biphenyl-4-yl)ethyl]amino}-1H-pyrazolo[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	183	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM281311 (4-(4-{[2-(biphenyl-4-yl)ethyl]amino}-1H-pyrazolo[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	157	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM281311 (4-(4-{[2-(biphenyl-4-yl)ethyl]amino}-1H-pyrazolo[4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.23E+3	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair