BDBM281321 N-benzyl-2-[6-(2-ethyl-4-hydroxyphenyl)-1H-pyrazolo[4,3-c]pyridin-4-yl]-1,2,3,4-tetrahydroisoquinoline-5-carboxamide formate::US10022376, Example 117

SMILES: CCc1cc(O)ccc1-c1cc2[nH]ncc2c(n1)N1CCc2c(C1)cccc2C(=O)NCc1ccccc1

InChI Key: InChIKey=OYAQOINYWAAURV-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 281321   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Human)	BDBM281321 (N-benzyl-2-[6-(2-ethyl-4-hydroxyphenyl)-1H-pyrazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.20	n/a	n/a	n/a	n/a	7.4	25
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM281321 (N-benzyl-2-[6-(2-ethyl-4-hydroxyphenyl)-1H-pyrazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	25
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM281321 (N-benzyl-2-[6-(2-ethyl-4-hydroxyphenyl)-1H-pyrazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41.6	n/a	n/a	n/a	n/a	7.4	25
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					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM281321 (N-benzyl-2-[6-(2-ethyl-4-hydroxyphenyl)-1H-pyrazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	425	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM281321 (N-benzyl-2-[6-(2-ethyl-4-hydroxyphenyl)-1H-pyrazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.20	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM281321 (N-benzyl-2-[6-(2-ethyl-4-hydroxyphenyl)-1H-pyrazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM281321 (N-benzyl-2-[6-(2-ethyl-4-hydroxyphenyl)-1H-pyrazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41.6	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM281321 (N-benzyl-2-[6-(2-ethyl-4-hydroxyphenyl)-1H-pyrazol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	425	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair