BDBM281326 3-ethyl-4-[4-(8-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl]phenolformate::US10022376, Example 122

SMILES: CCc1cc(O)ccc1-c1cc2[nH]ncc2c(n1)N1CCc2cccc(OC)c2C1

InChI Key: InChIKey=CMXPYUOPFJEEGA-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 281326   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Human)	BDBM281326 (3-ethyl-4-[4-(8-methoxy-3,4-dihydroisoquinolin-2(1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14.9	n/a	n/a	n/a	n/a	7.4	25
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM281326 (3-ethyl-4-[4-(8-methoxy-3,4-dihydroisoquinolin-2(1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25.1	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM281326 (3-ethyl-4-[4-(8-methoxy-3,4-dihydroisoquinolin-2(1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	78.1	n/a	n/a	n/a	n/a	7.4	25
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					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM281326 (3-ethyl-4-[4-(8-methoxy-3,4-dihydroisoquinolin-2(1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	478	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM281326 (3-ethyl-4-[4-(8-methoxy-3,4-dihydroisoquinolin-2(1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14.9	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM281326 (3-ethyl-4-[4-(8-methoxy-3,4-dihydroisoquinolin-2(1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25.1	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM281326 (3-ethyl-4-[4-(8-methoxy-3,4-dihydroisoquinolin-2(1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	78.1	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM281326 (3-ethyl-4-[4-(8-methoxy-3,4-dihydroisoquinolin-2(1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	478	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair