BDBM289898 1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-naphthalen-2-ylmethyl}- piperidine-4-carboxylic acid dimethylamide::US9573957, Example 38

SMILES CN(C)C(=O)C1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1

InChI Key InChIKey=GEZYQLVGPXEJFF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289898   

TargetLeukotriene A-4 hydrolase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM289898(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-naph...)
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent