BDBM289986 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-carbonyl}-piperazin-1-yl)-ethanone (112)::US9573957, Example 112

SMILES CC(=O)N1CCN(C(=O)c2coc3cc(Oc4ccc(-c5ccn[nH]5)cn4)ccc23)CC1

InChI Key InChIKey=SAUKQOWPDVGKJX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289986   

TargetLeukotriene A-4 hydrolase(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 289986BDBM289986(1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benz...)
Affinity DataIC50: 1.90nMpH: 7.5 T: 2°CAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent