BDBM29526 2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate::CHEMBL286136::ML 10302::ML10302

SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1

InChI Key InChIKey=RVFIAQAAZUEPPE-UHFFFAOYSA-N

Data  20 KI  1 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 29526   

Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 4E receptor expressed in C6 glial cells using [3H]-GR-113,808 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(RAT)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  1.07nMAssay Description:Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(RAT)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  1.07nMAssay Description:Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]-GR-113,808 as radioligand in rat striatumMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to YFP fused 5HT4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  3.69nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  3.69nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4D receptor isoform expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]GR-113808 from human 5HT4e receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  5nM ΔG°:  -11.3kcal/mole EC50:  51nMpH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  5nMAssay Description:Binding affinity for 5-HT4 receptor using [3H]-GR-113,808More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]-GR-113,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to Rluc fused 5HT4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  7.98nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  7.98nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4C receptor isoform expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  8.40nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4A receptor isoform expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  8.40nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  10.7nMAssay Description:Binding affinity was determined against cloned 5-hydroxytryptamine 4B receptor isoform expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  10.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  730nMAssay Description:Binding affinity was measured on 5-hydroxytryptamine 3 receptor using [3H]-BRL 43694 as radioligand in rat posterior cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataKi:  782nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]-BRL-43694 in rat posterior cortexMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at 5-HT4 receptor in guinea pig ileum assessed as increase in response to electrical stimulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Umr C8076 (Cnrs)

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataEC50:  2.5nMAssay Description:Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataEC50:  4nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataEC50:  4nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(RAT)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM29526(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Affinity DataIC50:  2.40nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity was determined by the relaxation of the carbachol-contracted rat esophageal tunica muscularis mucosaeMore data for this Ligand-Target Pair
In DepthDetails Article