BDBM30344 Cipemastat::Trocade
SMILES CN1C(=O)N(C[C@@H]([C@@H](CC2CCCC2)C(=O)N2CCCCC2)C(=O)NO)C(=O)C1(C)C
InChI Key InChIKey=GFUITADOEPNRML-SJORKVTESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 30344
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
Affinity DataKi: 0.530nM ΔG°: -12.5kcal/mole IC50: 3.5nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibition of matrix metalloprotease-1 (MMP-1).Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of matrix metalloprotease-13 (MMP-13).Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of matrix metalloprotease-8 (MMP-8).Checked by AuthorMore data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 56nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
Affinity DataKi: 59nMAssay Description:Inhibition of matrix metalloprotease-9 (MMP-9).Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 154nMAssay Description:Inhibition of matrix metalloprotease-2 (MMP-2).Checked by AuthorMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 230nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 527nMAssay Description:Inhibition of matrix metalloprotease-3 (MMP-3).Checked by AuthorMore data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 7.00E+3nMAssay Description:Inhibition of Matrix metalloprotease-1 (MMP1)More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 527nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP9)More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
Affinity DataIC50: 154nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMT: 2°CAssay Description:Test compounds were serially diluted in deep well plates, and an aliquot of the inhibitor solutions was transferred to a Biomek deep well plate conta...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 87nMT: 2°CAssay Description:Test compounds were serially diluted in deep well plates, and an aliquot of the inhibitor solutions was transferred to a Biomek deep well plate conta...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.30nMT: 2°CAssay Description:Test compounds were serially diluted in deep well plates, and an aliquot of the inhibitor solutions was transferred to a Biomek deep well plate conta...More data for this Ligand-Target Pair