BDBM304331 (R)-5-cyclopropyl-2-(2-isopropyl-4-(3-(methylsulfonyl)phenyl)piperazin-1-yl)pyrimidine::US10144715, Compound 7-5

SMILES CC(C)[C@@H]1CN(CCN1c1ncc(cn1)C1CC1)c1cccc(c1)S(C)(=O)=O

InChI Key InChIKey=GKSVBRSAJNOJOL-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 304331   

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304331((R)-5-cyclopropyl-2-(2-isopropyl-4-(3-(methylsulfo...)
Affinity DataKi:  26nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304331((R)-5-cyclopropyl-2-(2-isopropyl-4-(3-(methylsulfo...)
Affinity DataEC50:  313nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304331((R)-5-cyclopropyl-2-(2-isopropyl-4-(3-(methylsulfo...)
Affinity DataKi:  346nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent