BDBM313222 N-[3-[[2-[4-(4-ethylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide ::US10167264, Compound 9

SMILES CCN1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)cc1

InChI Key InChIKey=MQUIYZHBFOBMJN-UHFFFAOYSA-N

Data  3 Kd

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 313222   

TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Jiangsu Medolution Ltd

US Patent
LigandPNGBDBM313222(N-[3-[[2-[4-(4-ethylpiperazin-1-yl)anilino]-5-(tri...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H28F3N7O/c1-3-23(37)31-19-6-5-7-20(16-19)32-24-22(26(27,28)29)17-30-25(34-24)33-18-8-10-21(11-9-18)36-14-12-35(4-2)13-15-36/h3,5-11,16-17H,1,4,12-15H2,2H3,(H,31,37)(H2,30,32,33,34)
Affinity DataKd:  0.0370nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEpidermal growth factor receptor [1-745,751-1210](Homo sapiens (Human))
Jiangsu Medolution Ltd

US Patent
LigandPNGBDBM313222(N-[3-[[2-[4-(4-ethylpiperazin-1-yl)anilino]-5-(tri...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H28F3N7O/c1-3-23(37)31-19-6-5-7-20(16-19)32-24-22(26(27,28)29)17-30-25(34-24)33-18-8-10-21(11-9-18)36-14-12-35(4-2)13-15-36/h3,5-11,16-17H,1,4,12-15H2,2H3,(H,31,37)(H2,30,32,33,34)
Affinity DataKd:  4nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangsu Medolution Ltd

US Patent
LigandPNGBDBM313222(N-[3-[[2-[4-(4-ethylpiperazin-1-yl)anilino]-5-(tri...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H28F3N7O/c1-3-23(37)31-19-6-5-7-20(16-19)32-24-22(26(27,28)29)17-30-25(34-24)33-18-8-10-21(11-9-18)36-14-12-35(4-2)13-15-36/h3,5-11,16-17H,1,4,12-15H2,2H3,(H,31,37)(H2,30,32,33,34)
Affinity DataKd:  15nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid